Where you sit on the airplane will make or break your trip. The best seat on the airplane is the First Class bulkhead, but most of us aren’t rich, so the second best is the coach bulkhead seat. If you can’t get either of these, try for the back row, aisle seat if you are alone. If you and another adult will be traveling with the kids then I suggest one of you booking the window seat, one book the aisle seat and hope no one takes the middle. The good news is if someone does take the middle seat, they will definitely be willing to switch seats with you so you guys can sit together. If you have multiple children traveling with you, the same concept applies, except that you will be purchasing a seat for the additional children.
Time of departure/arrival
When booking tickets for our trip, I think a lot about what time we leave and what time we will be arriving. If I can, I try to book departure for a time after our normal waking time and an arrival that gives us plenty of time before the normal bedtime. However, this is not always possible and if you are traveling internationally, you need to see our other post about dealing with jetlag and kids.